Intravenous hypertonic saline to reduce intraocular pressure

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The effect of intravenous infusion of hypertonic saline on the intra-ocular pressure.

THE exchange of water between blood and eye fluids is very rapid (Kinsey, Grant, and Cogan, 1942) in comparison with the migration of sodium chloride across the blood aqueous barrier. Consequently, on making the blood hypertonic by the intravenous injection of sodium chloride, water should be withdrawn from the eye, and the intra-ocular pressure lowered. Qualitatively, such an effect has been d...

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The use of HS solutions has been shown to reduce ICP both in animal models and in human studies in a variety of underlying disorders, even in cases refractory to treatment with hyperventilation and mannitol. There are several possible mechanisms of action, and important complications such as central pontine myelinolysis and intracranial hemorrhage have not been reported in the human studies. Di...

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IN this issue of ANESTHESIOLOGY, Rozet et al. present the findings of a comprehensive study comparing two hyperosmolar agents, hypertonic saline (HS) and mannitol, for brain relaxation during craniotomy. This work calls into question whether sufficient information is now available to advocate substitution of mannitol with HS to promote brain relaxation during routine craniotomy. It was discover...

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ژورنال

عنوان ژورنال: Acta Ophthalmologica

سال: 2012

ISSN: 1755-375X

DOI: 10.1111/j.1755-3768.2012.02474.x